IBD
Surveillance in inflammatory bowel disease: the HELIOS trial
te Groen M, Wijnands A, den Broeder N, et al. Surveillance in inflammatory bowel disease: white light endoscopy with segmental re-inspection versus dye-based chromoendoscopy – a multi-arm randomised controlled trial (HELIOS). Gut 2025; 74: 547-556. doi: 10.1136/gutjnl-2024-333446.
Early tumour necrosis factor antagonist treatment prevents perianal fistula development in children with Crohn’s disease
Adler J, Gadepalli S, Rahman M, et al. Early tumour necrosis factor antagonist treatment prevents perianal fistula development in children with Crohn’s disease: post hoc analysis of the RISK study. Gut 2025; 74: 539-546. doi: 10.1136/gutjnl-2024-333280
Hepatology
Hepatic TM6SF2 activates antitumour immunity to suppress metabolic dysfunction-associate steatotic liver disease-related hepatocellular carcinoma
Zhang Y, Xie M, Wen J, et al. Hepatic TM6SF2 activates antitumour immunity to suppress metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma and boosts immunotherapy. Gut 2025; 74: 640-652. doi: 10.1136/gutjnl-2024-333154
Effects of tenofovir disoproxil fumarate on intrahepatic viral burden and liver immune microenvironment in patients with chronic hepatitis B
Pan D, Soulette C, Aggarwal A, et al. Effects of tenofovir disoproxil fumarate on intrahepatic viral burden and liver immune microenvironment in patients with chronic hepatitis B. Gut 2025; 74: 628–638. doi: 10.1136/gutjnl-2024-332526.
Pancreas
Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus
Tan J, Mao X, Cheng H, et al. Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus. Gut 2025; 74: 603-612. doi: 10.1136/gutjnl-2024-333329
Colon
Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome
Schwarzmueller L, Adam R, Moreno L, et al. Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome. Gut 2025; 74: 571-585. doi: 10.1136/gutjnl-2024-332752.
Reviewers
Dr Gaurav Nigam, NIHR Clinical Research Fellow, University of Oxford and Oxford University
Hospitals, Oxford, UK
Dr Brian Ho, Honorary Clinical Research Fellow and Gastroenterology Registrar, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK
Dr Anahita Sharma, Gastroenterology Registrar, Department of Gastroenterology, Arrowe Park Hospital, Wirral, UK
Dr Nurulamin Noor, Clinical Lecturer in Gastroenterology, University of Cambridge and Cambridge University Hospitals, Cambridge, UK
Dr Keith Pohl, JAG Fellow and Gastroenterology Registrar, Torbay and South Devon NHS Foundation Trust, Torquay, UK
Dr Akudo Nwaogu, Gastroenterology Registrar, Department of Gastroenterology, Kingston
Foundation Hospital Trust, London, UK
BSG GUT Highlights is edited by Dr Philip J Smith, Honorary Consultant Luminal Gastroenterologist, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon, Liverpool, UK. Dr Smith is the Digital and Education Editor of GUT, Editor in chief of Frontline Gastroenterology and Associate Editor of BMJ Open Gastroenterology.
Funding
The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests: None declared.
Provenance and peer review: Not commissioned; internally peer reviewed.