Colon
Early detection of colorectal cancer using aberrant circulating cell- free mitochondrial DNA fragmentomics
Wang S, Peng F, Dang M, et al. Early detection of colorectal cancer using aberrant circulating cell- free mitochondrial DNA fragmentomics. Gut 2025; 74: 961–970. doi:10.1136/gutjnl-2024-333533.
Coeliac Disease
Serological screening for coeliac disease in an adult general population: the HUNT study
Andersen I, Lukina P, Dyrli O, et al. Serological screening for coeliac disease in an adult general population: the HUNT study. Gut 2025; 74: 918-925. doi: 10.1136/gutjnl-2024-333886.
Inflammatory Bowel Disease
Stem Cell Transplantation for Refractory Crohn’s: Outcomes and Immune Mechanisms
Guisado D, Talware S, Wang X, et al. Reparative immunological consequences of stem cell transplantation as a cellular therapy for refractory Crohn’s disease. Gut 2025; 74: 894-905. doi: 10.1136/gutjnl-2024-333558.
Endoscopy
Carbon footprinting and environmental impact of gastrointestinal endoscopy procedures at a tertiary care institution
Rughwani H, Kalapala R, Katrevula A, et al. Carbon footprinting and environmental impact of gastrointestinal endoscopy procedures at a tertiary care institution: a prospective multi-dimensional assessment. Gut 2025; 74: 926-934. doi: 10.1136/gutjnl-2024-332471.
Hepatology
Multiomics analysis of immune correlatives in hepatocellular carcinoma patients treated with tremelimumab plus durvalumab
Myojin Y, Babaei S, Trehan R, et al. Multiomics analysis of immune correlatives in hepatocellular carcinoma patients treated with tremelimumab plus durvalumab. Gut 2025; 74(6): 983-995. doi: 10.1136/gutjnl-2024-334026.
Pancreas
Risk factors for pancreatic cancer in individuals with intraductal papillary mucinous neoplasms and no high-risk stigmata during up to 5 years of surveillance
Hamada T, Oyama H, Nevo D, et al. Risk factors for pancreatic cancer in individuals with intraductal papillary mucinous neoplasms and no high-risk stigmata during up to 5 years of surveillance: a prospective longitudinal cohort study. Gut 2025; 74(6): 971-982. doi: 10.1136/gutjnl-2024-333259.
Reviewers
- Dr Catherine Hsu, Hepatology Registrar, King’s College Hospital NHS Foundation Trust, London, UK
- Dr Kelly Chatten, Bolton NHS Foundation Trust, Bolton, UK
- Dr Khurum Hakeem, Gastroenterology Registrar, University Hospital of North Durham, Durham, UK
- Dr Abisoye Akintimehin, Gastroenterology Registrar London North West University Healthcare NHS Trust, London, UK
- Dr James Sun, Pre-doctoral Clinical Research Excellence Fellow, Francis Crick Institute and King’s College London, London, UK
- Dr Sam Withington, Gastroenterology Registrar, North West London, London, UK
BSG Gut Highlights is edited by Dr Philip J Smith, Honorary Consultant Luminal Gastroenterologist, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon, Liverpool, UK. Dr Smith is the Digital and Education Editor of Gut, Editor in chief of Frontline Gastroenterology and Associate Editor of BMJ Open Gastroenterology.
Funding: The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests: None declared.
Provenance and peer review: Not commissioned; internally peer reviewed.