Neurogastroenterology
Predictors of response to low-dose amitriptyline for irritable bowel syndrome
Wright-Hughes A, Ow P, Alderson S, et al. Predictors of response to low-dose amitriptyline for irritable bowel syndrome and efficacy and tolerability according to subtype: post hoc analyses from the ATLANTIS trial. Gut 2025; 74(5): 728-739. doi: 10.1136/gutjnl-2024-334490.
Endoscopy
Margin thermal ablation in large non-pedunculated colorectal polyps
Gauci J, Mandarino F, Kerrison C, et al. Margin thermal ablation eliminates size as a risk factor for recurrence after piecemeal endoscopic mucosal resection of large non-pedunculated colorectal polyps. Gut 2025; 74(5): 752-760. doi: 10.1136/gutjnl-2024-333563.
Hepatology
Glucagon-like peptide-1 receptor agonist use is associated with a lower risk of major adverse liver-related outcomes
Celsa C, Pennisi G, Tulone A, et al. Glucagon-like peptide-1 receptor agonist use is associated with a lower risk of major adverse liver-related outcomes: a meta-analysis of observational cohort studies. Gut 2025; 74: 815-824. doi: 10.1136/gutjnl-2024-334591.
Colon
Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of a colonic tuft cell transcriptional activator
Rajasekaran V, Harris B, Osborn R, et al. Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2. Gut 2025; 74(5): 787-803. doi: 10.1136/gutjnl-2024-332121.
Inflammatory Bowel Disease
Low-coverage whole genome sequencing of low- grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis
Al-Bakir I, Curtius K, Cresswell G, et al. Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis. Gut 2025;74(5):740-751. doi:10.1136/gutjnl-2024-333353
Gut Microbiota
Fasting-mimicking diet-enriched Bifidobacterium pseudolongum suppresses colorectal cancer
Nan K, Zhong Z, Yue Y, et al. Fasting-mimicking diet-enriched Bifidobacterium pseudolongum suppresses colorectal cancer by inducing memory CD8+ T cells. Gut 2025; 74(5): 775-786. doi: 10.1136/gutjnl-2024-333020.
Reviewers
Dr Benjamin Norton, Doctoral Research Student, Cleveland Clinic London (CCL) and University College London (UCL), London, UK
Dr Mohsen Subhani, Nottingham University Hospitals NHS Trust, Nottingham, UK
Dr Mie Thu Ko, NIHR ST4 Academic Clinical Fellow, University of East Anglia and Norfolk and Norwich University Hospital, Norwich, UK
Dr Benjamin Zare, St Mark’s National Bowel Hospital & Academic Institute, London, UK
Dr Ahmed El-Sayed, Clinical Research Fellow, UCL, London, UK
Dr Puneet Chhabra, Staff Specialist Gastroenterologist, Royal Hobart Hospital, Hobart, Tasmania, Australia
BSG GUT Highlights is edited by Dr Philip J Smith, Honorary Consultant Luminal Gastroenterologist, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon, Liverpool, UK. Dr Smith is the Digital and Education Editor of GUT, Editor in chief of Frontline Gastroenterology and Associate Editor of BMJ Open Gastroenterology.
Funding
The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests: None declared.
Provenance and peer review: Not commissioned; internally peer reviewed.