Hepatology
Rice-derived recombinant human serum albumin as an alternative to human plasma for patients with decompensated liver cirrhosis: a randomised, double-blind, positive-controlled and non-inferiority trial
Niu J, Gao Y, Wang G, et al. Rice-derived recombinant human serum albumin as an alternative to human plasma for patients with decompensated liver cirrhosis: a randomised, double-blind, positive-controlled and non-inferiority trial. Gut 2025; 74: 1476-1485. doi: 10.1136/gutjnl-2025-335577
Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence
Rodrigo-Torres D, Kilpatrick A, Ferreira-Gonzalez S, et al. Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence. Gut 2025; 74:1500-1513. doi: 10.1136/gutjnl-2024-334094
Pancreas
Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial.
Huang L, Feng Z, Yang W, et al. Parecoxib sequential with imrecoxib for occurrence and remission of severe acute pancreatitis: a multicentre, double-blind, randomised, placebo-controlled trial. Gut 2025;74(9): 1467-1475. doi: 10.1136/gutjnl-2024-334038.
Colon
Colorectal cancer incidence after the first surveillance colonoscopy and the need for ongoing surveillance: a retrospective, cohort analysis
Robbins E, Wooldrage K, Rutter M, et al. Colorectal cancer incidence after the first surveillance colonoscopy and the need for ongoing surveillance: a retrospective, cohort analysis. Gut 2025; 74: 1419-1429. doi: 10.1136/gutjnl-2024-334242
Combining faecal haemoglobin, iron deficiency anaemia status and age can improve colorectal cancer risk prediction in patients attending primary care with bowel symptoms: a retrospective observational study
Digby J, Nobes J, Strachan J, et al. Combining faecal haemoglobin, iron deficiency anaemia status and age can improve colorectal cancer risk prediction in patients attending primary care with bowel symptoms: a retrospective observational study. Gut 2025; 74: 1430-1436. doi: 10.1136/gutjnl-2024-334248.
Reviewers
Dr Catherine Hsu, Post-ST5 Hepatology Clinical Research fellow, Queen Mary University of London, London, UK
Dr Khurum Hakeem, Gastroenterology Registrar, University Hospital of North Durham, Durham, UK
Dr Abisoye Akintimehin, Gastroenterology Registrar, London North West University Healthcare NHS Trust, London, UK
Dr Kelly Chatten, Bolton NHS Foundation Trust, Bolton, UK
Dr James Sun, Pre-doctoral Clinical Research Excellence Fellow, Francis Crick Institute and King’s College London, London, UK
BSG GUT Highlights is edited by Dr Philip J Smith, Honorary Consultant Luminal Gastroenterologist, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon, Liverpool, UK. Dr Smith is the Digital and Education Editor of GUT, Editor in chief of Frontline Gastroenterology and Associate Editor of BMJ Open Gastroenterology.
Funding
The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests: None declared.
Provenance and peer review: Not commissioned; internally peer reviewed.