Gut Microbiota
Dietary whey protein protects against Crohn's disease via the gut phageome and bacteriome
Su R, Wen W, Jin Y, et al. Dietary whey protein protects against Crohn's disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome. Gut 2025; 74(8): 1246-1260. doi: 10.1136/gutjnl-2024-334516.
Gut microbial-derived N-acetylmuramic acid alleviates colorectal cancer via the AKT1 pathway
Hu M, Xu Y, Wang Y, et al. Gut microbial-derived N-acetylmuramic acid alleviates colorectal cancer via the AKT1 pathway. Gut 2025; 74(8): 1230-1245. doi: 10.1136/gutjnl-2024-332891.
Hepatology
Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2
Xu H, Wu Z, Qin J, et al. Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2. Gut 2025; 74(8): 1321-1334. doi: 10.1136/gutjnl-2024-334318
Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis
Trebicka J, Aguilar F, Queiroz Farias A, et al. Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis. Gut 2025; 74(8):1293-1307. doi: 10.1136/gutjnl-2024-333876.
Stomach
Extracellular Vesicle–Derived lncRNA Signature Enables Early, Non-Invasive Detection of Early-Onset Gastric Cancer
Guo X, Wang W, Cheng X, et al. Diagnostic efficacy of an extracellular vesicle-derived lncRNA-based liquid biopsy signature for the early detection of early-onset gastric cancer. Gut 2025; 74(8): 1209-1218. doi: 10.1136/gutjnl-2024-333657.
Pancreas
Targeting MXD1 sensitises pancreatic cancer to trametinib
Zhang S, Deng S, Liu J, et al. Targeting MXD1 sensitises pancreatic cancer to trametinib. Gut 2025; 74(8): 1262-1278. doi: 10.1136/gutjnl-2024-333408.
Reviewers
Dr Benjamin Norton, Doctoral Research Student, Cleveland Clinic London (CCL) and University College London (UCL), London, UK
Dr Mohsen Subhani, Nottingham University Hospitals NHS Trust, Nottingham, UK
Dr Mie Thu Ko, NIHR ST4 Academic Clinical Fellow, University of East Anglia and Norfolk and Norwich University Hospital, Norwich, UK
Dr Benjamin Zare, St Mark’s National Bowel Hospital & Academic Institute, London, UK
Dr Ahmed El-Sayed, Clinical Research Fellow, UCL, London, UK
Dr Puneet Chhabra, Staff Specialist Gastroenterologist, Royal Hobart Hospital, Hobart, Tasmania, Australia
BSG GUT Highlights is edited by Dr Philip J Smith, Honorary Consultant Luminal Gastroenterologist, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon, Liverpool, UK. Dr Smith is the Digital and Education Editor of GUT, Editor in chief of Frontline Gastroenterology and Associate Editor of BMJ Open Gastroenterology.
Funding
The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests: None declared.
Provenance and peer review: Not commissioned; internally peer reviewed.