Intestinal inflammation
24-Nor-ursodeoxycholic acid improves intestinal inflammation
Zhu C, Boucheron N, Al-Rubaye O, et al. 24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting TH17 pathogenicity and transdifferentiation. Gut 2025; 74(7): 1079-1093. doi: 10.1136/gutjnl-2024-333297.
Endoscopy
Rectal diclofenac versus indomethacin for prevention of post-ERCP pancreatitis (DIPPP)
, et al, Rectal diclofenac versus indomethacin for prevention of post-ERCP pancreatitis (DIPPP): a multicentre, double-blind, randomised, controlled trial. Gut 2025; 74(7): 1094-1102. doi: 10.1136/gutjnl-2024-334466.
Multicentre randomised controlled trial of a self-assembling haemostatic gel to prevent delayed bleeding following endoscopic mucosal resection (PURPLE Trial)
Drews J, Zachäus M, Kleemann T, et al. Multicentre randomised controlled trial of a self-assembling haemostatic gel to prevent delayed bleeding following endoscopic mucosal resection (PURPLE Trial). Gut 2025; 74(7): 1103-1111. doi: 10.1136/gutjnl-2024-334229.
Neurogastroenterology
Characterisation of MRGPRX2+ mast cells in irritable bowel syndrome
Decraecker L, Cuende Estévez M, Van Remoortel S, et al. Characterisation of MRGPRX2+ mast cells in irritable bowel syndrome. Gut 2025; 74(7): 1068-1077. doi: 10.1136/gutjnl-2024-334037.
Hepatology
Bioprinting functional hepatocyte organoids derived from human stem cells to treat liver failure
Li G, He J, Shi J, et al. Bioprinting functional hepatocyte organoids derived from human chemically induced pluripotent stem cells to treat liver failure. Gut 2025; 74(7): 1150-1164. doi: 10.1136/gutjnl-2024-333885.
Reviewers
Dr Nurulamin Noor, Clinical Lecturer in Gastroenterology, University of Cambridge and Cambridge University Hospitals, Cambridge, UK
Dr Gaurav Nigam, NIHR Clinical Research Fellow, University of Oxford and Oxford University Hospitals, Oxford, UK
Dr Anahita Sharma, Gastroenterology Registrar, Department of Gastroenterology, Arrowe Park Hospital, Wirral, UK
Dr Brian Ho, Honorary Clinical Research Fellow and Gastroenterology Registrar, Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK
Dr Keith Pohl, JAG Fellow and Gastroenterology Registrar, Torbay and South Devon NHS Foundation Trust, Torquay, UK
BSG GUT Highlights is edited by Dr Philip J Smith, Honorary Consultant Luminal Gastroenterologist, Royal Liverpool Hospital, Liverpool University Hospitals NHS Foundation Trust, Mount Vernon, Liverpool, UK. Dr Smith is the Digital and Education Editor of GUT, Editor in chief of Frontline Gastroenterology and Associate Editor of BMJ Open Gastroenterology.
Funding
The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests: None declared.
Provenance and peer review: Not commissioned; internally peer reviewed.