Latest Update

Latest update 

Professor Julian Marchesi (ICL, Cardiff University) has taken over as the new chair for the Gut Microbiota for Health Expert Panel, from Professor Tariq Iqbal (University Hospital Birmingham). Professor Nigel Klein (University College London) has become the new vice-chair.  Professor Marchesi is looking forward to his tenure as chair and working with the panel to explore this exciting new area of human biology.

 

In other news, members of the Gut Microbiota for Health Expert Panel were part of a joint British Society of Gastroenterology and Healthcare Infection Society working group aimed at setting up UK evidence-based guidelines for the provision and governance of faecal microbiota transplantation (FMT) as a treatment for recurrent or refractory Clostridium difficile infection and other conditions. The guidelines have now been published in the two relevant journals:

 

Mullish BH, Quraishi MN, Segal JP, et al (2018) The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines

Gut 67:1920-1941.

 

Mullish BH, Quraishi MN, Segal JP, et al (2018) The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines

Journal of Hospital Infection 100 (Suppl 1):S1-S31.

 

An invited review by members of the panel on the topic of the gut microbiota and IBD is also in press

Segal JP, Mullish B, Quraishi MN, Acharjee A, Williams HRT, Iqbal T, Hart A, Marchesi JR et al. (2018) The application of omics techniques to understand the role of the gut microbiota in inflammatory bowel disease, Therapeutic Advances in Gastroenterology, ISSN: 1756-2848

Please also note a forthcoming science masterclass on the morning of the 20th June 2019 at the next BSG conference: ‘The Bench to bedside Faecal Microbiota Transplantation (FMT)’, organised by Professor Barry Campbell and Professor John McLaughlin. The programme can be downloaded here.

 

Dr Linda Thomas

Secretariat, Gut Microbiota for Health Expert Panel

December 2018


 

About the Panel

The Gut Microbiota for Health Expert Panel represents a group of multi-disciplinary members (including primary and secondary care clinicians, microbiologists, dietitians and research scientists) with expertise and interest in the gut microbiota and its role in health and disease. The Group is under the auspices of the British Society of Gastroenterology Research Committee.

The group was formed in 2013 and now includes over 50 members who meet twice a year, arrange meetings and workshops on key topics related to the microbiota and publish articles in high impact journals, as well as writing articles to enhance understanding with the public. As the Group has grown, it is now organised into Special Interest Groups (SIGs) but maintains the over-arching meetings to ensure continuity and sharing of expertise and interest.

The goals of the group are: to increase awareness and understanding among clinicians of the gut microbiota and its impact on health; to be a 'go-to' address for clinicians (GPs, gastroenterologists, nurses and allied health professionals) for defining what is currently reliably known in this field; and to drive scientific and academic interest in the gut microbiota primarily in gastrointestinal and liver disease - although our SIGs also cover nutrition, the gut-brain axis and infectious disease. Our website (https://www.bsg.org.uk/research/gut-microbiota-for-health-expert-panel.html) lists links to up-to-date papers selected by the SIG as being particularly relevant and topical. Each SIG will take turns to post articles here with news of developments in this rapidly evolving field of biology.

 

In particular, the group aims to:

  • To map the science and reach consensus on what is known and what is not yet known
  • To develop guidelines to promote good practice
  • To draft consensus statements on areas of interest for UK GPs
  • To identify gaps in knowledge and research foci
  • To identify research and development areas in this field that would advance understanding and lead to patient benefit

 

Current Members

Current Members

  • Julian R. Marchesi (Chair; Cardiff University / Imperial College London)
  •  Nigel Klein (Vice-Chair; University College London)
  • Tariq Iqbal (Chair Emeritus; University Hospital Birmingham)
  • Dagmar Alber (UCL Great Ormond Institute of Child Health)
  • Ramesh Arasaradnam (University of Warwick)
  • Qasim Aziz (Royal London Hospital)
  • Mona Bajaj-Elliott (UCL Great Ormond Institute of Child Health)
  • Kelly Bicknell (Queen Alexandra Hospital, Portsmouth)
  • Judith Breuer (University College London)
  • Matthew Brookes (The Royal Wolverhampton NHS Trust)
  • Barry Campbell (University of Liverpool)
  • Simon Carding (Institute for Food Research, Norwich)
  • Bernard Corfe (University of Sheffield)
  • Jamie Dalrymple (PCSG)
  • Ted Dinan (University College Cork)
  • Ngozi Elumgo (Norfolk and Norwich University Hospitals)
  • Anton Emmanuel (University College London)
  • Andrew Flatt (Queen Alexandra Hospital, Portsmouth)
  • Konstantinos Gerasimidis (University of Glasgow)
  • Rohma Ghani (Imperial College London)
  • Simon Goldenberg (Guy’s & St Thomas’ NHS Foundation Trust)
  • Julie Harrington (Guts UK)
  • Ailsa Hart (former Chair; St Mark's Hospital, Harrow)
  • Peter Hawkey (University of Birmingham)
  • Gideon Hirschfield (University of Birmingham)
  • Georgina Hold (University of Aberdeen)
  • Pali Hungin (Durham University)
  • Brian Jones (University of Brighton)
  • Darina Kohotouva (The Royal Marsden NHS Foundation Trust)
  • Nigel Klein (University College London)
  • Trevor Lawley (Sanger Institute, Cambridge)
  • James Lindsay (Barts and the London NHS Trust)
  • Giles Major (University of Nottingham)
  • Victoria McCune (PHE Birmingham)
  • Pamela McDonald-Kuhne (Durham University)
  • Patricia Macnair (PCSG)
  • John McLaughlin (University of Manchester)
  • Ben Mullish (Imperial College London)
  • Ann Muls (The Royal Marsden NHS Foundation Trust)
  • Mohammed Nabil Quraishi (University of Birmingham)
  • Arjan Narbad (Institute of Food Research, Norwich)
  • Sarah O'Brien (University of Liverpool)
  • Vishal Patel (KCL Institute of Liver Studies)
  • Ian Roberts (University of Manchester)
  • Ian Rowland (formerly University of Reading)
  • Jonathan Segal (Imperial College London)
  • Naveen Sharma (Heart of England NHS Foundation)
  • Debbie Shawcross (King's College London)
  • Liz Sheridan (Poole Hospital NHS Foundation Trust)
  • Jonathan Sutton (Ysbyty Gwynedd, Bangor)
  • Jonathan Swann (Imperial College London)
  • John Threlfall (formerly Public Health England)
  • Kevin Whelan (King's College London)
  • Leila White (Lancashire Teaching Hospitals NHS Foundation Trust)
  • Peter Whorwell (University of Manchester)
  • Horace Williams (Imperial College London)
  • Charlotte Woodhouse (Maidstone and Tunbridge Wells NHS Trust)

Secretariat

Linda Thomas (Society for Applied Microbiology).

Message from the Chair Emeritus

The group has been successful in achieving several publications for the clinical and scientific audience, as well as the public. The group published a major scientific review in GUT, "The gut microbiota and host health: A new clinical frontier" (Marchesi et al. GUT 2016; 65:330-339), which is in the top 5% of all research outputs scored by Altmetric. In this article, the group outlines: the current understanding of the gut microbiota; dietary modulation of the microbiota; assesses the role of probiotics, prebiotics and polyphenols; and describes obesity-related diseases, liver disease, inflammatory bowel diseases and colorectal cancer and the microbiota.
 
The article "The ecologist will see you now" outlines for the public some of the fascinating facts about the microbiota, explaining that "we're not individuals, we're ecosystems full of bacteria and understanding how these microbes interact with our bodies is set to transform medicine".
The group published a systematic review and meta-analysis of the efficacy of faecal microbiota transplantation (FMT) for the treatment of recurrent and refractory Clostridium difficile infection (Quraishi et al. APT 2017; 46:479-493) and is currently completing a comprehensive NICE-approved FMT practice guideline, which is a joint BSG/HIS venture. It is aimed to publish this in 2018.
 
The Group has contributed to two successful BSG Research Workshops: "The Microbiome, Dysbiosis and GI Disease" (11 April 2014) and "Faecal Microbiota Transplantation: Bench, Bedside, Courtroom?" 11 September 2015. In 2018 we plan to hold a workshop focussed on developing a national FMT service, which will follow the annual BSG meeting in Liverpool (details to follow).
 
The Group is also developing a review for primary care professionals, explaining the current understanding of the gut microbiota's impact on gut disorders.
 
This is an exciting and fast evolving area of research and the Group welcome involvement from interested colleagues in this multi-disciplinary field.
 

Professor Tariq Iqbal

Chair, Gut Microbiota for Health Expert Panel


Gut Microbiota for Health Expert Panel: Charter

Structure

A cross disciplinary education & interest group under the auspices of the British Society of Gastroenterology (BSG Research Committee)

Mission Statement

  • To help increase awareness and understanding among clinicians of the gut microbiota and its impact on health
  • To be a 'go-to' address for UK clinicians (GPs, gastroenterologists, nurses and allied health professionals) for defining what is currently reliably known in this field
  • To drive scientific and clinical interest in the gut microbiota in gastrointestinal and liver disease, including those with an autoimmune element

Objectives

  • To facilitate the sharing of knowledge on the gut microbiota between academics, clinicians and researchers
  • To map the science and reach consensus on what is known and what is not yet known
  • To draft consensus statements on areas of interest for UK GPs
  • To identify gaps in knowledge and research foci
  • To identify R&D areas in this field that would advance understanding and lead to patient benefit
  • To develop guidelines to ensure the safe and effective manipulation of the gut microbiota for therapeutic purposes (e.g. faecal microbiota transplantation (FMT) and responsible antibiotic use)

Achievements

Current focus

  • To make significant contribution to the governance of FMT in the UK, and to set up a UK registry of groups conducting FMT
  • To publish articles on the gut microbiota for primary care professionals, to explain the current understanding about the impact of the gut microbiome on gut disorders
  • To disseminate information about the group and ensure it represents a broad and relevant range of expertise

Special Interest Groups

Special Interest Groups (with further information)

• Colorectal cancer (Lead: Julian Marchesi)

• Diet and nutritional interventions (Lead: Ian Rowland)

• Faecal Microbiota Transplantation (Lead: Tariq Iqbal)

• Gut-brain axis (Lead: Ted Dinan)

•             Gut microbiome (general) (Lead: Julian Marchesi)

•             Gut virome (Lead: Brian Jones)

•             Inflammatory bowel disease (Lead: Georgina Hold)

•             Irritable bowel syndrome (Lead: Anton Emmanuel)

•             Infectious disease (including antimicrobial resistance) (Lead: Andrew Flatt)

•             Liver (Lead: Debbie Shawcross)

•             Metabonomics (Lead: Jonathan Swann)

•             Primary Care (Lead: Jamie Dalrymple)

 

 

Funding

The panel members meet twice a year in London, and this year there will be an additional meeting in Liverpool. The ad hoc travel and refreshment costs of all the meetings in 2018 are covered by an unconditional education grant from PHARMACOSMOS. The BSG covers costs for secretariat support. Funding for specific projects is subject to separate agreement.