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Delivery of a comprehensive service for the detection of Lynch syndrome

With the introduction of Lynch syndrome testing in the National Genomic Test Directory (GTD), all cancer MDTs, cancer alliances, and genomics alliances are expected to be providing access to this testing, in line with NICE guidance for colorectal cancers and endometrial cancers. Through the NHS GMS Alliances, there is an opportunity to build on the work of the GLHs to align pathways and processes across NHS GMS Alliance regions to drive standardisation, equity of access, and clinical benefit at a national level.

Gastroenterologists are now able to counsel and offer genetic testing for a range of genetic conditions, including Lynch syndrome, as per the GTD. We have developed training modules to upskill gastroenterologists and other cancer MDT clinicians who wish to provide this testing. A link to relevant training modules is available here.

This work is linked to the national project, the goals of which are to:

  • Determine geographical variation and barriers to access testing pathways across all relevant providers in the geography
  • Embed ubiquitous testing for Lynch syndrome in colorectal and endometrial cancer patients across the geography, linked to mainstreaming pathways for multi-professional clinical practice
  • Extend Lynch syndrome screening across all relevant tumour types, including further embedding endometrial and introducing new pathways in urinary tract, prostate, upper gastrointestinal, and pancreatobiliary cancers.
  • Demonstrate clinical impact of testing pathways on access to personalised/stratified care following a cancer diagnosis
  • Develop and embed infrastructure to support pathway transformation and quality improvement in patient care working towards regional Lynch syndrome networks linking primary, secondary, and tertiary care

For further information and other queries, please feel free to get in touch with me below.

Dr Kevin J Monahan FRCP PhD
Consultant Gastroenterologist
Lynch Syndrome & Family Cancer Clinic
St Mark’s Hospital
Harrow HA1 3UJ
London, United Kingdom


Useful Links

Local Cancer MDT Lynch Champion

Handbook supporting local systems to implement Lynch syndrome pathways