S D Ryder
These guidelines cover two areas of clinical practice relating to HCC: firstly, its diagnosis, including surveillance of high risk individuals; and secondly, treatment of the patient where the diagnosis has been made. HCC remains one of the commonest malignant diseases in the world but it has not previously been a leading cause of death in the Western world. There is now conclusive evidence from the USA and a strong suggestion from the UK that HCC is becoming a more common cancer, primarily due to the HCV epidemic. These guidelines relate to adult medical practice; high risk paediatric conditions predisposing to HCC and the management of paediatric patients with HCC will not be considered.