Research News

NIHR Grant Applications - seminar & support event

Monday, 27 February 2017 10:08

Are you planning to submit a grant application to NIHR? The NIHR Research Design Service (RDS) is holding a one-day event aimed at helping you to improve your chances of success. The morning seminar session is open to anyone to come and hear Simon Goodwin, RfPB Programme Manager for the South West, and RDS advisers give presentations on what makes a good grant proposal. The afternoon support session of one-to-one appointments is for those who would like to discuss their own proposal with Simon and/or an RDS adviser. Events are taking place from 10:30-16:00 on 27 April 2017 in Bristol and on 28 June 2017 in Bournemouth. Find out more.

Expression of interest in joining an NIHR panel

Friday, 24 February 2017 10:35

If you might be interested in joing an NIHR panel, please complete the form. More information about the work of the panels can be found on the NIHR website.

METRIC Study closed for recruitment - add-on study funded

Friday, 24 February 2017 10:15

The NIHR HTA funded Metric study (MR Enterography or ulTRasound In Crohn’s disease; “Diagnostic accuracy for the extent and activity of newly diagnosed and relapsed Crohn’s disease: a multicentre prospective comparison of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over”) has closed to recruitment; data collection and analysis are underway. The research team led by Prof Stuart Taylor and Dr Andrew Plumb were successful in securing £358,183 funding from the HTA for an add on study (MRI enterography as a predictor of disabling disease in newly diagnosed Crohn's disease) to develop a prognostic model for future disabling disease in those newly diagnosed with Crohn's disease. In particular, the group will investigate whether findings on MR enterography at diagnosis are predictive of a worse long-term outcome, over and above existing prognostic markers. Co-investigators: Ailsa Hart, Andrew Plumb, Gauraang Bhatnagar, Nicola Muirhead, John Hamlin, Stuart Bloom, Susan Mallett, Ilan Jacobs, Susan Tebbs, Simon Travis, Stephen Morris, Steve Halligan.

Crohn's Disease trial funding success: cine MRI

Friday, 24 February 2017 10:06

Joint collaborations between members of the British Society of Gastrointestinal and Abdominal Radiology (BSGAR) and the BSG have led to recent grant success from the NIHR. Led by Prof Stuart Taylor and Dr Andrew Plumb, the team has been awarded £895,292 by NIHR EME to investigate “Small bowel motility quantified by cine MRI as a predictor of long term response in patients with Crohn's disease commencing biological therapy”. The trial will recruit from 10 centers and perform dynamic cine MRI imaging of the small bowel in those commencing biological therapies for active disease. Small bowel motility is reduced by active inflammation and this can be quantified using MRI and specialist analysis software. The study will test if early improvement in small bowel motility after commencing therapy is better predictive of 1 year response or remission than CRP or calprotectin. An embedded mechanistic study led by Dr Gordon Moran will explore the relationship between gut peptides, inflammatory cytokines, aberrant small bowel motility on MRI, and patient abdominal symptoms. A team led by Prof Ailsa Hart will investigate the effect of body composition on patient response. Co-investigators: Gordon Moran, Ailsa Hart, Alex Menys, Andrew Plumb, Stuart Bloom, Tariq Ahmad, Ilan Jacobs, Susan Tebbs, Caroline Dore, Simon Travis, Steve Halligan.

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