Research News

BSG members win substantial funding for clinical trial

Tuesday, 07 January 2014 15:22

Several BSG members were co-applicants on a recent successful application for substantial funding of a clinical trial in hepatology. Prof Mark Thursz, Dr Steve Ryder, Prof Matthew Cramp, Dr Paul Richardson and Dr Stuart McPherson are among a group represented by Dr Alastair O’Brien. The group received £1.6 million from the Health Innovation Challenge Fund (joint Wellcome Trust and Department of Health) for ATTIRE (Albumin To prevenT Infection in chronic liveR failure).

The money will fund a multi-centre, clinical, phase II and phase III trial at 15 sites that will examine whether administration of albumin to patients admitted with decompensated liver failure, in order to increase plasma levels to near normal, will prevent hospital acquired infection. Dr O'Brien's local clinical research network (LCRN) will fund the research nurse costs (>£1million).

Over 100,000 patients are admitted to hospital every year with advanced liver cirrhosis; infection is their most common problem. Dr O’Brien and his team have shown that, in these patients, leukocyte function is markedly impaired by an up-regulation of the hormone Prostaglandin E2; infusion of albumin can reverse this process by binding and neutralising its effects. Albumin is widely considered by hepatologists to be beneficial in liver disease but no putative mechanism had been identified, so no consensus had developed for how to prescribe it. Dr O’Brien and colleagues aim to repurpose albumin as an immunity-restoring drug to improve leukocyte function in patients with advanced cirrhosis and therefore improve their ability to fight off infection. They hope to demonstrate that its use will lead to reduced rates of nosocomial infection and mortality and shorter hospital stays, thereby reducing health care costs.

Paediatric European Digestive Diseases Clinical Research Network (PEDDCReN) Survey

Tuesday, 10 December 2013 14:18

Nick Croft, Julian Thomas, Nikhil Thapar (UK Members of the PEDDCReN Steering Group) and Varsha Tailor (PEDDCReN Project Manager) invite you to participate in a 5-minute survey that will allow the project team to identify the interests of the departments across Europe, in order to determine what expertise and resources are available for setting up and running clinical trials in this speciality. For further details and access to the survey itself, please click here.

Paediatric European Digestive Diseases Clinical Research Network – PEDDCReN

Tuesday, 12 November 2013 15:06

PEDDCReN is an exciting new initiative with the key aim of forming a clinical trials network to study (and ultimately provide) effective medicines for paediatric patients in the speciality of Gastroenterology, Hepatology and Nutrition. It was established with the support of LINKS funding from the UEG and is led by the BSG in collaboration with various European societies and ENPR-EMA (The European Network of Paediatric Research at the European Medicines Agency). The project will support both industry and non-industry investigators in running high quality multi-centre clinical trials and your involvement is welcome.

IBD Nixon Twin and Multiplex Registry

Wednesday, 06 November 2013 12:45

UK gastroenterologists are invited to refer concordant and discordant twin pairs, as well as families where three or more first degree relatives have an IBD diagnosis, to the twin/multiplex registry. We will collect epidemiological data and invite members to donate to a biobank. This will become a powerful research resource that will be available for research collaborations in the future. Further information about how to refer twins or families is available from Hannah Gordon, Senior Clinical Research Fellow (Gastroenterology), IBD Nixon TAM Registry Co-Investigator, Chelsea and Westminster Hospital, This e-mail address is being protected from spambots. You need JavaScript enabled to view it

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