MRC - Scientists discover how 'super enzyme' speeds up DNA repair
Tuesday, 06 September 2016 09:24
Scientists from the University of Sussex have discovered how an enzyme, known as PARP3, helps to accelerate the repair of DNA.
In the body, mutations can arise from DNA damage that is not repaired properly, leading to disease, including cancer and neurodegenerative disease. New research funded by the MRC and Cancer Research UK, led by the laboratories of Professor Keith Caldecott and Professor Laurence Pearl at the University of Sussex’s Genome Damage and Stability Centre, has identified how the enzyme PARP3, short for poly(ADP-ribose) polymerase 3, recognises and signals the presence of broken DNA strands.
Research has shown that the PARP3 enzyme is involved in the DNA repair process and helps to maintain the integrity of the genetic code, but until now the precise DNA repair activation mechanism triggered by the enzyme was unclear.
Apply to join MRC boards and panels
Monday, 05 September 2016 15:06
The Medical Research Council (MRC) annual board and panel recruitment exercise has commenced, inviting applications to join MRC boards and panels from April 2017. The MRC values the diverse skills and experience of the members of its Boards and Panels and is committed to achieving equality of treatment for all. The MRC particularly welcomes applications from currently under-represented groups, female and ethnic minority researchers and from researchers with disabilities.
Mentoring for young scientists
Friday, 02 September 2016 10:27
A unique opportunity for aspiring researchers! The UEG Mentoring Programme, part of the Young GI Network, provides you with guidance from senior scientists such as Research Prize Awardee Rebecca Fitzgerald or Rising Star Jakub Fichna. To receive a personal invitation and secure one of the limited places, make sure to register by September 8 (special rates for fellows apply).
Basic and translational research at UEG Week 2016
Friday, 02 September 2016 10:19
Follow the Basic and Translational Science Pathway at UEG Week 2016 and attend sessions tailored specifically to interests of scientists in digestive health. Start planning your itinerary; e.g. by marking sessions like Immunotherapy in cancer and learn about immunotherapy and the mechanism of action by Stefan Kubicka and colleagues.
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