Research News

Crohn's Disease trial funding success: cine MRI

Friday, 24 February 2017 10:06

Joint collaborations between members of the British Society of Gastrointestinal and Abdominal Radiology (BSGAR) and the BSG have led to recent grant success from the NIHR. Led by Prof Stuart Taylor and Dr Andrew Plumb, the team has been awarded £895,292 by NIHR EME to investigate “Small bowel motility quantified by cine MRI as a predictor of long term response in patients with Crohn's disease commencing biological therapy”. The trial will recruit from 10 centers and perform dynamic cine MRI imaging of the small bowel in those commencing biological therapies for active disease. Small bowel motility is reduced by active inflammation and this can be quantified using MRI and specialist analysis software. The study will test if early improvement in small bowel motility after commencing therapy is better predictive of 1 year response or remission than CRP or calprotectin. An embedded mechanistic study led by Dr Gordon Moran will explore the relationship between gut peptides, inflammatory cytokines, aberrant small bowel motility on MRI, and patient abdominal symptoms. A team led by Prof Ailsa Hart will investigate the effect of body composition on patient response. Co-investigators: Gordon Moran, Ailsa Hart, Alex Menys, Andrew Plumb, Stuart Bloom, Tariq Ahmad, Ilan Jacobs, Susan Tebbs, Caroline Dore, Simon Travis, Steve Halligan.

Informed Consent

Wednesday, 22 February 2017 14:02

Are you looking to learn about valid informed consent? Find a course in your area.

Listen to the 'Business of Discovery' podcasts

Wednesday, 22 February 2017 13:28

The NIHR have announced a series of podcasts from Professor Allan Gaw. They range from a discussion of the nurse's changing role in research, to systematic reviews and meta-analyses, to various aspects of clinical trials, including ethics and research misconduct. Each podcast is 10-15 minutes long.

NIHR Study Support Service Route Map

Wednesday, 22 February 2017 09:57

Planning to deliver a study in the NHS? Take a look at the route map to see when and how support can be offered by the NIHR Study Support Service.

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