METRIC Study closed for recruitment - add-on study funded
Friday, 24 February 2017 10:15
The NIHR HTA funded Metric study (MR Enterography or ulTRasound In Crohn’s disease; “Diagnostic accuracy for the extent and activity of newly diagnosed and relapsed Crohn’s disease: a multicentre prospective comparison of magnetic resonance enterography and small bowel ultrasound compared to a reference standard in those aged 16 and over”) has closed to recruitment; data collection and analysis are underway. The research team led by Prof Stuart Taylor and Dr Andrew Plumb were successful in securing £358,183 funding from the HTA for an add on study (MRI enterography as a predictor of disabling disease in newly diagnosed Crohn's disease) to develop a prognostic model for future disabling disease in those newly diagnosed with Crohn's disease. In particular, the group will investigate whether findings on MR enterography at diagnosis are predictive of a worse long-term outcome, over and above existing prognostic markers. Co-investigators: Ailsa Hart, Andrew Plumb, Gauraang Bhatnagar, Nicola Muirhead, John Hamlin, Stuart Bloom, Susan Mallett, Ilan Jacobs, Susan Tebbs, Simon Travis, Stephen Morris, Steve Halligan.
Crohn's Disease trial funding success: cine MRI
Friday, 24 February 2017 10:06
Joint collaborations between members of the British Society of Gastrointestinal and Abdominal Radiology (BSGAR) and the BSG have led to recent grant success from the NIHR. Led by Prof Stuart Taylor and Dr Andrew Plumb, the team has been awarded £895,292 by NIHR EME to investigate “Small bowel motility quantified by cine MRI as a predictor of long term response in patients with Crohn's disease commencing biological therapy”. The trial will recruit from 10 centers and perform dynamic cine MRI imaging of the small bowel in those commencing biological therapies for active disease. Small bowel motility is reduced by active inflammation and this can be quantified using MRI and specialist analysis software. The study will test if early improvement in small bowel motility after commencing therapy is better predictive of 1 year response or remission than CRP or calprotectin. An embedded mechanistic study led by Dr Gordon Moran will explore the relationship between gut peptides, inflammatory cytokines, aberrant small bowel motility on MRI, and patient abdominal symptoms. A team led by Prof Ailsa Hart will investigate the effect of body composition on patient response. Co-investigators: Gordon Moran, Ailsa Hart, Alex Menys, Andrew Plumb, Stuart Bloom, Tariq Ahmad, Ilan Jacobs, Susan Tebbs, Caroline Dore, Simon Travis, Steve Halligan.
RDS Residential Grant Writing Retreat
Wednesday, 22 February 2017 14:23
The Research Design Service is offering health and social care professionals across the South West and South Central regions a unique opportunity for health and social care professionals across the South West and South Central regions to attend a week-long Residential Grant Writing Retreat at Dillinton House, Ilminster from 4-8 September 2017. Applications for the Retreat must be submitted by 1pm Wednesday 26 April 2017. More details
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