Research

UK-PSC

A UK Collaberative Study to Determine the Genetic Basis of Primary Sclerosing Cholangitis (UK-PSC).

This is an observational case-control genome wide association study. The primary aim of the study is to determine the genetic factors predisposing and contributing to the development of PSC. The secondary objective is to determine the molecular mechanisms by which genetic variants associated with PSC cause disease. Also from the patient and clinician questionnaire epidemiological information will be collected, which would provide us with phenotypic characteristics of the largest cohort of PSC patients in the British population.

Update:October 2010

To date, 1400 patients have been recruited from over 120 NHS trusts and 1050 DNA samples have been collected, expecting to reach 1500 samples by December. Current recruitment is 40 new patients each month. There has been tremendous support from the UK CLRN research nurses who have helped with patient recruitment in the participating trusts. Approval awaited from a further 15 trusts in the UK including Northern Ireland. Please contact trial team if you need any further information regarding the study or recruitment process.

Dr Brijesh Srivastava
Clinical Research Fellow Addenbrooke’s Hospital, Cambridge.
Phone: 01223 769 088
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Dr Simon Rushbrook
Chief Investigator Consultant Hepatologist
Norfolk & Norwich University Hospital, Norwich.
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Also note the similar study: Investigation of the Genetic and Molecualar Pathogenesis of Primary Bilary Cirrhosis (PBC-GEN). For details of this please contact Dr George Mells (email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it )