Idiosyncratic Drug-induced Liver Injury Study
Formerly: Hepatic Adverse Drug Reactions Study
The international Drug-induced Liver Injury Consortium (iDILIC), a multi-national research group led jointly by Professor Ann Daly, Newcastle University and Dr Guruprasad Aithal, Nottingham Digestive Diseases Centre: NIHR Biomedical Research Unit is studying the genetic susceptibility to idiosyncratic drug-induced liver injury. The UK arm of the study, DILIGEN, is a portfolio study adopted by Comprehensive Local Research Networks (CLRN) nationally.
The study, involves collecting DNA from cases and suitable controls for a genome wide association study (GWAS) with the aim of identifying polymorphisms predictive of the development of drug-related liver injury and hence allowing the possibility of prevention. We will be grateful to physicians treating idiosyncratic drug-induced liver injury cases, particularly BSG members, to put us in contact with suitable patients.
Patient who developed one of the following due to drug-induced liver injury are suitable to be included:
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