Research

Family Gastric Cancer Study

The Familial Gastric Cancer Study aims to identify new gastric cancer predisposing genes and to improve the treatment and management of individuals with an inherited predisposition to gastric cancer.

Summary of Research

Hereditary cancer syndromes have provided the samples for linkage analysis that made possible the identification of novel cancer-causing genes. Diffuse type gastric cancer remains one of the more common and aggressive human cancers. We propose to collect information from families with clustered cases of gastric cancer and identify pedigrees, which suggest a pattern of autosomal dominant inheritance. Linkage and candidate gene analysis in these pedigrees will be used to identify a potential major susceptibility locus. Mutations have been identified rarely in individuals under the age of 50 so it appears justified to search for germline mutations in gastric cancer cases diagnosed under the age of 45.

In addition, the second part of the study 'The Hereditary Diffuse Gastric Cancer Registry' will collect detailed molecular pathological and clinical information (including quality of life) for cases in whom a mutation in E-cadherin (CDH1) has been identified. This is in order to inform the future management of these families.

Further information about the research study may be found in the full study protocol.

Inclusion Criteria:

  • Any family with two or more documented cases of diffuse gastric cancer in first or second degree relatives, with at least one diagnosed before the age of 50.
  • Three or more documented cases of diffuse gastric cancer in first or second degree relatives, diagnosed at any age.
  • Any individual diagnosed with diffuse gastric cancer before the age of 40 without a family history.
  • Individuals and families diagnosed with both diffuse gastric cancer and lobular breast cancer (including one before the age of 50 years).

Referral to the study

Referrals to the study can be made by contacting the Research Nurse:

Sue Richardson
Tel: 01223 348933
This e-mail address is being protected from spambots. You need JavaScript enabled to view it

Clinicians who have identified patients will need to contact the Research Nurse. A permission slip can be given to the patient to sign which will allow the research team in Cambridge to contact them to provide further information about the study.

Individuals may also contact the Research Nurse directly by telephone or email.

Further information about the research study may be found in the study protocol:

View full study protocol [ 380 kb ]

Details of the study are on Cancer Research UK's website: www.cancerresearchuk.org

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